The ERC-20 standard is a foundational protocol within the Ethereum blockchain that defines a set of rules for creating and managing fungible tokens. Introduced in 2015, it has become the backbone of many tokenized assets and applications on Ethereum.

One key significance of ERC-20 is its role in fostering interoperability. Tokens adhering to the ERC-20 standard can seamlessly interact with Ethereum-based wallets, decentralized applications (dApps), and exchanges. This uniformity simplifies token creation and integration, significantly reducing development complexity.

The standard has also democratized tokenization, allowing developers and organizations to create cryptocurrencies or utility tokens without building a blockchain from scratch. This capability has fueled the growth of Initial Coin Offerings (ICOs), decentralized finance (DeFi), and other innovative use cases.

Moreover, ERC-20 has played a pivotal role in the broader adoption of blockchain technology. Enabling the rapid deployment of new tokens has accelerated innovation and the proliferation of blockchain projects across various industries.

However, while ERC-20 has been transformative, it is not without limitations, such as inefficiencies in gas usage and transaction handling. Nonetheless, it remains a cornerstone of Ethereum's ecosystem, shaping the evolution of decentralized finance and tokenized economies.